Pinned Loading

1. GLP1-oral-PBPK GLP1-oral-PBPK Public

   PK-Sim's GUI is Windows-only, but since ospsuite 12.4 the solver runs natively on Apple Silicon through rSharp/.NET. Models are authored once in a Windows 11 ARM VM (VMware Fusion), exported as .pk…

   HTML

2. CAR-T-BCMA-QSP CAR-T-BCMA-QSP Public

   Mechanistic QSP of BCMA CAR-T in multiple myeloma: antigen-escape dynamics, cross-validated R↔Julia.

3. ODEs-QSP ODEs-QSP Public

   Mechanistic ODE QSP models: 13-state GBM tumor-immune + 14-state complement-neurodegeneration. MATLAB SimBiology + Python.

   HTML

4. OPT-CDISC-pipeline OPT-CDISC-pipeline Public

   Independent CDISC mapping of a real published RCT — SDTM → ADaM → TLG in R, built from a wide non-CDISC source extract. Every mapping decision documented; 38 validation checks against raw. sdtm.oak…

   R 1

5. Multi-omics-R Multi-omics-R Public

   a Multi-Omics Analysis Suite — Shiny App

   R 1

6. bispecific_molecule_kissrun bispecific_molecule_kissrun Public

   A kinetic screen for T-cell-engaging bispecifics. Killing needs a brief contact; cytokine needs a sustained one — the gap between those two dwell times is the therapeutic window. Illustrative param…

   Python